Target Information
Target General Infomation | |||||
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Target ID |
T78932
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Former ID |
TTDNC00412
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Target Name |
TYK2
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Gene Name |
TYK2
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Synonyms |
Nonreceptor tyrosineprotein kinase TYK2; TYK2
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Target Type |
Research
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Function |
Probably involved in intracellular signal transduction bybeing involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain.
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BioChemical Class |
Kinase
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UniProt ID | |||||
EC Number |
EC 2.7.10.2
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Sequence |
MPLRHWGMARGSKPVGDGAQPMAAMGGLKVLLHWAGPGGGEPWVTFSESSLTAEEVCIHI
AHKVGITPPCFNLFALFDAQAQVWLPPNHILEIPRDASLMLYFRIRFYFRNWHGMNPREP AVYRCGPPGTEASSDQTAQGMQLLDPASFEYLFEQGKHEFVNDVASLWELSTEEEIHHFK NESLGMAFLHLCHLALRHGIPLEEVAKKTSFKDCIPRSFRRHIRQHSALTRLRLRNVFRR FLRDFQPGRLSQQMVMVKYLATLERLAPRFGTERVPVCHLRLLAQAEGEPCYIRDSGVAP TDPGPESAAGPPTHEVLVTGTGGIQWWPVEEEVNKEEGSSGSSGRNPQASLFGKKAKAHK AVGQPADRPREPLWAYFCDFRDITHVVLKEHCVSIHRQDNKCLELSLPSRAAALSFVSLV DGYFRLTADSSHYLCHEVAPPRLVMSIRDGIHGPLLEPFVQAKLRPEDGLYLIHWSTSHP YRLILTVAQRSQAPDGMQSLRLRKFPIEQQDGAFVLEGWGRSFPSVRELGAALQGCLLRA GDDCFSLRRCCLPQPGETSNLIIMRGARASPRTLNLSQLSFHRVDQKEITQLSHLGQGTR TNVYEGRLRVEGSGDPEEGKMDDEDPLVPGRDRGQELRVVLKVLDPSHHDIALAFYETAS LMSQVSHTHLAFVHGVCVRGPENIMVTEYVEHGPLDVWLRRERGHVPMAWKMVVAQQLAS ALSYLENKNLVHGNVCGRNILLARLGLAEGTSPFIKLSDPGVGLGALSREERVERIPWLA PECLPGGANSLSTAMDKWGFGATLLEICFDGEAPLQSRSPSEKEHFYQRQHRLPEPSCPQ LATLTSQCLTYEPTQRPSFRTILRDLTRLQPHNLADVLTVNPDSPASDPTVFHKRYLKKI RDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKADCGPQHRSGWKQEIDILRTLYHEHII KYKGCCEDQGEKSLQLVMEYVPLGSLRDYLPRHSIGLAQLLLFAQQICEGMAYLHAQHYI HRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKEYKFYY ASDVWSFGVTLYELLTHCDSSQSPPTKFLELIGIAQGQMTVLRLTELLERGERLPRPDKC PCEVYHLMKNCWETEASFRPTFENLIPILKTVHEKYQGQAPSVFSVC |
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Pathways | |||||
KEGG Pathway | Osteoclast differentiation | ||||
Jak-STAT signaling pathway | |||||
Toxoplasmosis | |||||
Hepatitis C | |||||
Measles | |||||
Influenza A | |||||
Herpes simplex infection | |||||
Epstein-Barr virus infection | |||||
Pathway Interaction Database | IL27-mediated signaling events | ||||
Signaling events mediated by PTP1B | |||||
IL12-mediated signaling events | |||||
IL6-mediated signaling events | |||||
IL23-mediated signaling events | |||||
Reactome | Interleukin-6 signaling | ||||
MAPK3 (ERK1) activation | |||||
MAPK1 (ERK2) activation | |||||
Interferon alpha/beta signaling | |||||
Regulation of IFNA signaling | |||||
WikiPathways | Interferon type I signaling pathways | ||||
IL-4 Signaling Pathway | |||||
IL-6 signaling pathway | |||||
Oncostatin M Signaling Pathway | |||||
Interleukin-11 Signaling Pathway | |||||
Type III interferon signaling | |||||
Interferon alpha/beta signaling | |||||
References |
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