Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T67754
|
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| Former ID |
TTDR00094
|
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| Target Name |
Transketolase
|
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| Gene Name |
TKT
|
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| Synonyms |
TK; TKT
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| Target Type |
Research
|
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| Function |
Catalyzes the transfer ofa two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.
|
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| BioChemical Class |
Transferases of aldehyde or ketone residues
|
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| UniProt ID | |||||
| EC Number |
EC 2.2.1.1
|
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| Sequence |
MESYHKPDQQKLQALKDTANRLRISSIQATTAAGSGHPTSCCSAAEIMAVLFFHTMRYKS
QDPRNPHNDRFVLSKGHAAPILYAVWAEAGFLAEAELLNLRKISSDLDGHPVPKQAFTDV ATGSLGQGLGAACGMAYTGKYFDKASYRVYCLLGDGELSEGSVWEAMAFASIYKLDNLVA ILDINRLGQSDPAPLQHQMDIYQKRCEAFGWHAIIVDGHSVEELCKAFGQAKHQPTAIIA KTFKGRGITGVEDKESWHGKPLPKNMAEQIIQEIYSQIQSKKKILATPPQEDAPSVDIAN IRMPSLPSYKVGDKIATRKAYGQALAKLGHASDRIIALDGDTKNSTFSEIFKKEHPDRFI ECYIAEQNMVSIAVGCATRNRTVPFCSTFAAFFTRAFDQIRMAAISESNINLCGSHCGVS IGEDGPSQMALEDLAMFRSVPTSTVFYPSDGVATEKAVELAANTKGICFIRTSRPENAII YNNNEDFQVGQAKVVLKSKDDQVTVIGAGVTLHEALAAAELLKKEKINIRVLDPFTIKPL DRKLILDSARATKGRILTVEDHYYEGGIGEAVSSAVVGEPGITVTHLAVNRVPRSGKPAE LLKMFGIDRDAIAQAVRGLITKA |
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| Inhibitor | 1-Methoxy-2-[2-(2-Methoxy-Ethoxy]-Ethane | Drug Info | [1] | ||
| Pathways | |||||
| BioCyc Pathway | Pentose phosphate pathway | ||||
| Pentose phosphate pathway (non-oxidative branch) | |||||
| KEGG Pathway | Pentose phosphate pathway | ||||
| Metabolic pathways | |||||
| Biosynthesis of antibiotics | |||||
| Carbon metabolism | |||||
| Biosynthesis of amino acids | |||||
| PANTHER Pathway | Pentose phosphate pathway | ||||
| PathWhiz Pathway | Pentose Phosphate Pathway | ||||
| Warburg Effect | |||||
| WikiPathways | Metabolism of carbohydrates | ||||
| Integration of energy metabolism | |||||
| Pentose Phosphate Pathway | |||||
| References | |||||
| REF 1 | How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. | ||||
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