Target Information
Target General Infomation | |||||
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Target ID |
T66976
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Former ID |
TTDS00060
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Target Name |
Alcohol dehydrogenase
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Gene Name |
AKR1A1
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Synonyms |
Aldehyde reductase; Aldo-keto reductase family 1 member A1; AKR1A1
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Target Type |
Research
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Function |
Catalyzes the NADPH-dependent reductionof a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. In vitro substrates include succinic semialdehyde, 4- nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D- glucuronic acid. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN).
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BioChemical Class |
Short-chain dehydrogenases reductases
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Target Validation |
T66976
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UniProt ID | |||||
EC Number |
EC 1.1.1.2
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Sequence |
MAASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIYGNEPEIGEAL
KEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFER GDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRP AVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEK YGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIV PMLTVDGKRVPRDAGHPLYPFNDPY |
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Pathways | |||||
BioCyc Pathway | Superpathway of tryptophan utilization | ||||
Tryptophan degradation via tryptamine | |||||
KEGG Pathway | Glycolysis / Gluconeogenesis | ||||
Pentose and glucuronate interconversions | |||||
Glycerolipid metabolism | |||||
Metabolic pathways | |||||
Biosynthesis of antibiotics | |||||
Degradation of aromatic compounds | |||||
WikiPathways | Metapathway biotransformation | ||||
Benzo(a)pyrene metabolism | |||||
References | |||||
Ref 529899 | Bioorg Med Chem. 2009 Feb 1;17(3):1244-50. Epub 2008 Dec 24.Correlation of binding constants and molecular modelling of inhibitors in the active sites of aldose reductase and aldehyde reductase. |
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