Target Information
Target General Infomation | |||||
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Target ID |
T57718
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Former ID |
TTDI02217
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Target Name |
Melanoma-associated antigenC2
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Gene Name |
MAGEC2
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Synonyms |
CT10; Cancer/testis antigen 10; Hepatocellular carcinomaassociated antigen 587; MAGEC2 antigen; MAGEE1 antigen; MAGEC2
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Target Type |
Clinical Trial
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Disease | Non-small cell lung cancer [ICD10: C33-C34] | ||||
Function |
Proposed to enhance ubiquitin ligase activity of RING- type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination in presence of Ubl-conjugating enzyme UBE2H leading to p53/TP53 degradation. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzymes (E2) at the E3:substrate complex.
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BioChemical Class |
Melanoma associated antigen family
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UniProt ID | |||||
Sequence |
MPPVPGVPFRNVDNDSPTSVELEDWVDAQHPTDEEEEEASSASSTLYLVFSPSSFSTSSS
LILGGPEEEEVPSGVIPNLTESIPSSPPQGPPQGPSQSPLSSCCSSFSWSSFSEESSSQK GEDTGTCQGLPDSESSFTYTLDEKVAELVEFLLLKYEAEEPVTEAEMLMIVIKYKDYFPV ILKRAREFMELLFGLALIEVGPDHFCVFANTVGLTDEGSDDEGMPENSLLIIILSVIFIK GNCASEEVIWEVLNAVGVYAGREHFVYGEPRELLTKVWVQGHYLEYREVPHSSPPYYEFL WGPRAHSESIKKKVLEFLAKLNNTVPSSFPSWYKDALKDVEERVQATIDTADDATVMASE SLSVMSSNVSFSE |
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Drugs and Mode of Action | |||||
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM) | |||||
TEP | EXP Info | ||||
References |
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