Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T45597
|
||||
| Target Name |
S6K kinase
|
||||
| Target Type |
Clinical Trial
|
||||
| Disease | Cancer [ICD9: 140-229; ICD10: C00-C96] | ||||
| Solid tumours [ICD9: 140-199, 210-229; ICD10: C00-D48] | |||||
| BioChemical Class |
Transferases (EC:2)
|
||||
| EC Number |
EC 2.7.11.1
|
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| Drugs and Mode of Action | |||||
| Drug(s) | LY-2584702 | Drug Info | Phase 1 | Cancer | [1], [2] |
| LY2780301 | Drug Info | Phase 1 | Cancer | [3] | |
| LYS-6KAKT1 | Drug Info | Phase 1 | Cancer | [4] | |
| MSC2363318A | Drug Info | Phase 1 | Solid tumours | [5] | |
| XL418 | Drug Info | Phase 1 | Solid tumours | [6] | |
| Modulator | LY-2584702 | Drug Info | |||
| LY2780301 | Drug Info | [7] | |||
| LYS-6KAKT1 | Drug Info | ||||
| MSC2363318A | Drug Info | [5] | |||
| XL418 | Drug Info | ||||
| References | |||||
| REF 1 | ClinicalTrials.gov (NCT01241461) A Study of LY2584702 in Solid Tumors. U.S. National Institutes of Health. | ||||
| REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8248). | ||||
| REF 3 | ClinicalTrials.gov (NCT01115751) A Study in Patients With Advanced or Metastatic Cancer. U.S. National Institutes of Health. | ||||
| REF 4 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800034531) | ||||
| REF 5 | ClinicalTrials.gov (NCT01971515) First-in-Human Dose Escalation Trial in Subjects With Advanced Malignancies. U.S. National Institutes of Health. | ||||
| REF 6 | ClinicalTrials.gov (NCT00460278) Study of XL418 in Adults With Solid Tumors. U.S. National Institutes of Health. | ||||
| REF 7 | A first-in-human phase I trial of LY2780301, a dual p70 S6 kinase and Akt Inhibitor, in patients with advanced or metastatic cancer. Invest New Drugs. 2015 Jun;33(3):710-9. | ||||
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