Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T43830
|
||||
| Former ID |
TTDS00102
|
||||
| Target Name |
5-hydroxytryptamine 2 receptor
|
||||
| Synonyms |
5-HT2 receptor; 5-HTB2; Serotonin receptor 2
|
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| Target Type |
Successful
|
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| Disease | Anxiety disorder [ICD9: 300, 311; ICD10: F32, F40-F42] | ||||
| Depression [ICD9: 311; ICD10: F30-F39] | |||||
| Hypertension [ICD9: 401; ICD10: I10-I16] | |||||
| BioChemical Class |
GPCR rhodopsin
|
||||
| Target Validation |
T43830
|
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| Drugs and Mode of Action | |||||
| Drug(s) | Cyclobenzaprine | Drug Info | Approved | Depression | [1], [2] |
| Ketanserin | Drug Info | Approved | Hypertension | [3], [4] | |
| Mianserin | Drug Info | Approved | Depression | [5], [6] | |
| Ritanserin | Drug Info | Discontinued in Phase 3 | Anxiety disorder | [7], [8] | |
| Antagonist | Cyclobenzaprine | Drug Info | [9] | ||
| Ketanserin | Drug Info | [10] | |||
| Metrenperone | Drug Info | [11], [12], [13], [14] | |||
| Mianserin | Drug Info | [15], [16], [17], [18] | |||
| Ritanserin | Drug Info | [19], [20], [21], [22] | |||
| References | |||||
| REF 1 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 021777. | ||||
| REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7152). | ||||
| REF 3 | Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77. Epub 2007 Feb 20. | ||||
| REF 4 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 88). | ||||
| REF 5 | Emerging treatments for depression. Expert Opin Pharmacother. 2006 Dec;7(17):2323-39. | ||||
| REF 6 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 135). | ||||
| REF 7 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 97). | ||||
| REF 8 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800000237) | ||||
| REF 9 | Torticollis under Cyclobenzaprine. Pharmacology. 2009 Jul 8;84(2):91-92. | ||||
| REF 10 | Nordexfenfluramine causes more severe pulmonary vasoconstriction than dexfenfluramine. Am J Physiol Lung Cell Mol Physiol. 2004 Mar;286(3):L531-8. Epub 2003 Nov 7. | ||||
| REF 11 | Cardiovascular response to intravenous administration of 5-hydroxytryptamine after type-2 receptor blockade, by metrenperone, in healthy calves. Vet J. 1999 Jan;157(1):31-7. | ||||
| REF 12 | Efficiency of 5-hydroxytryptamine receptor blockade as therapeutic measure during acute respiratory distress syndrome in double-muscled cattle. Zentralbl Veterinarmed A. 1993 Apr;40(3):185-93. | ||||
| REF 13 | Induction of serotonin-S2 receptor blockade during early or late stage of acute respiratory distress syndrome in double-muscled calves: a comparative study. Zentralbl Veterinarmed A. 1993 May;40(4):241-8. | ||||
| REF 14 | Pulmonary response to intravenous administration of 5-hydroxytryptamine after type-2 receptor blockade in healthy calves. Am J Vet Res. 1993 Jan;54(1):168-73. | ||||
| REF 15 | 5-HT2 receptor antagonists given in the acute withdrawal from daily cocaine injections can reverse established sensitization. Eur J Pharmacol. 2002 Oct 25;453(2-3):255-63. | ||||
| REF 16 | Lack of effect of some dopamine and non-dopamine receptor ligands on amphetamine-induced changes in the rat brain neuropeptide Y system. Pharmacol Rep. 2005 Nov-Dec;57(6):850-5. | ||||
| REF 17 | 5-HT2 and 5-HT3 receptors in the lateral parabrachial nucleus mediate opposite effects on sodium intake. Neuroscience. 2007 Jun 8;146(4):1453-61. Epub 2007 Apr 16. | ||||
| REF 18 | 5-HT reuptake and 5-HT2 receptors modulate capsaicin-evoked hypothermia in rats. Neurosci Lett. 2008 Jan 17;430(3):191-6. Epub 2007 Nov 5. | ||||
| REF 19 | Combined treatment of portal hypertension with ritanserin and propranolol in conscious and unrestrained cirrhotic rats. Hepatology. 1992 May;15(5):878-82. | ||||
| REF 20 | Effects of antipsychotics and reference monoaminergic ligands on marble burying behavior in mice. Behav Pharmacol. 2008 Mar;19(2):145-52. | ||||
| REF 21 | Hypersensitivity of 5-HT2 receptors in OCD patients. An increased prolactin response after a challenge with meta-chlorophenylpiperazine and pre-treatment with ritanserin and placebo. J Psychiatr Res.2008 Sep;42(11):894-901. Epub 2008 Jun 3. | ||||
| REF 22 | Characterization of contractile 5-hydroxytryptamine receptor subtypes in the in situ autoperfused kidney in the anaesthetized rat. Eur J Pharmacol. 2008 Sep 11;592(1-3):133-7. Epub 2008 Jul 4. | ||||
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