Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T42822
|
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| Former ID |
TTDS00437
|
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| Target Name |
Ferrochelatase
|
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| Gene Name |
FECH
|
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| Synonyms |
Heme synthetase; Protoheme ferro-lyase; FECH
|
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| Target Type |
Successful
|
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| Disease | Acne vulgaris [ICD9: 706.1; ICD10: L70.0] | ||||
| Function |
Catalyzes the ferrous insertion into protoporphyrin IX.
|
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| BioChemical Class |
Ferrochelatase
|
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| UniProt ID | |||||
| EC Number |
EC 4.99.1.1
|
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| Sequence |
MRSLGANMAAALRAAGVLLRDPLASSSWRVCQPWRWKSGAAAAAVTTETAQHAQGAKPQV
QPQKRKPKTGILMLNMGGPETLGDVHDFLLRLFLDRDLMTLPIQNKLAPFIAKRRTPKIQ EQYRRIGGGSPIKIWTSKQGEGMVKLLDELSPNTAPHKYYIGFRYVHPLTEEAIEEMERD GLERAIAFTQYPQYSCSTTGSSLNAIYRYYNQVGRKPTMKWSTIDRWPTHHLLIQCFADH ILKELDHFPLEKRSEVVILFSAHSLPMSVVNRGDPYPQEVSATVQKVMERLEYCNPYRLV WQSKVGPMPWLGPQTDESIKGLCERGRKNILLVPIAFTSDHIETLYELDIEYSQVLAKEC GVENIRRAESLNGNPLFSKALADLVHSHIQSNELCSKQLTLSCPLCVNPVCRETKSFFTS QQL |
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| Drugs and Mode of Action | |||||
| Drug(s) | Cholic Acid | Drug Info | Approved | Peroxisomal disorders; Synthesis disorders | [1] |
| Methyl aminolevulinate | Drug Info | Approved | Acne vulgaris | [2], [3] | |
| Inhibitor | Cholic Acid | Drug Info | [4] | ||
| Lead acetate | Drug Info | [5] | |||
| N-Methylmesoporphyrin | Drug Info | [4] | |||
| N-Methylmesoporphyrin Containing Copper | Drug Info | [4] | |||
| Activator | Methyl aminolevulinate | Drug Info | [6] | ||
| Pathways | |||||
| BioCyc Pathway | Heme biosynthesis | ||||
| Heme biosynthesis from uroporphyrinogen-III I | |||||
| KEGG Pathway | Porphyrin and chlorophyll metabolism | ||||
| Metabolic pathways | |||||
| PANTHER Pathway | Heme biosynthesis | ||||
| Pathway Interaction Database | HIF-1-alpha transcription factor network | ||||
| PathWhiz Pathway | Porphyrin Metabolism | ||||
| WikiPathways | Heme Biosynthesis | ||||
| Metabolism of porphyrins | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 609). | ||||
| REF 2 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 021415. | ||||
| REF 3 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015 | ||||
| REF 4 | How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. | ||||
| REF 5 | Ferrochelatase, a novel target for photodynamic therapy of cancer. Oncol Rep. 1999 Nov-Dec;6(6):1439-42. | ||||
| REF 6 | Low-dose methotrexate enhances aminolevulinate-based photodynamic therapy in skin carcinoma cells in vitro and in vivo. Clin Cancer Res. 2009 May 15;15(10):3333-43. Epub 2009 May 15. | ||||
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