Target Information

Target General Infomation
Target ID
T39523
Former ID
TTDI01951
Target Name
Phosphodiesterase (PDE) 7A
Gene Name
PDE7A
Synonyms
HCP1; High affinity cAMPspecific 3',5'cyclic phosphodiesterase 7A; TM22; PDE7A
Target Type
Discontinued
Disease Pain [ICD9: 338, 356.0, 356.8,780; ICD10: G64, G90.0, R52, G89]
Function
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction.
BioChemical Class
Phosphoric diester hydrolases
UniProt ID
Q13946
EC Number
EC 3.1.4.17
Sequence
MEVCYQLPVLPLDRPVPQHVLSRRGAISFSSSSALFGCPNPRQLSQRRGAISYDSSDQTA
LYIRMLGDVRVRSRAGFESERRGSHPYIDFRIFHSQSEIEVSVSARNIRRLLSFQRYLRS
SRFFRGTAVSNSLNILDDDYNGQAKCMLEKVGNWNFDIFLFDRLTNGNSLVSLTFHLFSL
HGLIEYFHLDMMKLRRFLVMIQEDYHSQNPYHNAVHAADVTQAMHCYLKEPKLANSVTPW
DILLSLIAAATHDLDHPGVNQPFLIKTNHYLATLYKNTSVLENHHWRSAVGLLRESGLFS
HLPLESRQQMETQIGALILATDISRQNEYLSLFRSHLDRGDLCLEDTRHRHLVLQMALKC
ADICNPCRTWELSKQWSEKVTEEFFHQGDIEKKYHLGVSPLCDRHTESIANIQIGFMTYL
VEPLFTEWARFSNTRLSQTMLGHVGLNKASWKGLQREQSSSEDTDAAFELNSQLLPQENR
LS
Drugs and Mode of Action
Drug(s) PF-3557156 Drug Info Discontinued in Phase 1 Pain [548590]
Modulator PF-3557156 Drug Info
Pathways
KEGG Pathway Purine metabolism
Morphine addiction
NetPath Pathway EGFR1 Signaling Pathway
TCR Signaling Pathway
IL2 Signaling Pathway
Reactome G alpha (s) signalling events
WikiPathways G Protein Signaling Pathways
Ectoderm Differentiation
References
Ref 548590Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800026842)

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