Target General Infomation
Target ID
T33367
Former ID
TTDR00222
Target Name
Aspartate aminotransferase, cytoplasmic
Gene Name
GOT1
Synonyms
Glutamate oxaloacetate transaminase-1; Transaminase A; GOT1
Target Type
Research
Function
Biosynthesis of L-glutamate from L-aspartate or L- cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3- mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain.
BioChemical Class
Transferases of nitrogenous groups
UniProt ID
EC Number
EC 2.6.1.3
Sequence
MAPPSVFAEVPQAQPVLVFKLTADFREDPDPRKVNLGVGAYRTDDCHPWVLPVVKKVEQK
IANDNSLNHEYLPILGLAEFRSCASRLALGDDSPALKEKRVGGVQSLGGTGALRIGADFL
ARWYNGTNNKNTPVYVSSPTWENHNAVFSAAGFKDIRSYRYWDAEKRGLDLQGFLNDLEN
APEFSIVVLHACAHNPTGIDPTPEQWKQIASVMKHRFLFPFFDSAYQGFASGNLERDAWA
IRYFVSEGFEFFCAQSFSKNFGLYNERVGNLTVVGKEPESILQVLSQMEKIVRITWSNPP
AQGARIVASTLSNPELFEEWTGNVKTMADRILTMRSELRARLEALKTPGTWNHITDQIGM
FSFTGLNPKQVEYLVNEKHIYLLPSGRINVSGLTTKNLDYVATSIHEAVTKIQ
Inhibitor Aminooxyacetate Drug Info [535443]
Maleic Acid Drug Info [551374]
Pathways
KEGG Pathway Alanine, aspartate and glutamate metabolism
Cysteine and methionine metabolism
Arginine and proline metabolism
Tyrosine metabolism
Phenylalanine metabolism
Phenylalanine, tyrosine and tryptophan biosynthesis
Metabolic pathways
Biosynthesis of antibiotics
Carbon metabolism
2-Oxocarboxylic acid metabolism
Biosynthesis of amino acids
NetPath Pathway TSH Signaling Pathway
IL2 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
PANTHER Pathway Asparagine and aspartate biosynthesis
PathWhiz Pathway Arginine and Proline Metabolism
Cysteine Metabolism
Phenylalanine and Tyrosine Metabolism
Tyrosine Metabolism
Reactome Gluconeogenesis
Amino acid synthesis and interconversion (transamination)
WikiPathways Glycolysis and Gluconeogenesis
Metabolism of amino acids and derivatives
Trans-sulfuration pathway
Metabolism of carbohydrates
Alanine and aspartate metabolism
References
Ref 535443Aspartate aminotransferase isotope exchange reactions: implications for glutamate/glutamine shuttle hypothesis. Am J Physiol Cell Physiol. 2002 Jun;282(6):C1404-13.
Ref 551374The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.

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