Target Information
Target General Infomation | |||||
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Target ID |
T33367
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Former ID |
TTDR00222
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Target Name |
Aspartate aminotransferase, cytoplasmic
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Gene Name |
GOT1
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Synonyms |
Glutamate oxaloacetate transaminase-1; Transaminase A; GOT1
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Target Type |
Research
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Function |
Biosynthesis of L-glutamate from L-aspartate or L- cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3- mercaptopyruvate sulfurtransferase (3MST). Hydrogen sulfide is an important synaptic modulator and neuroprotectant in the brain.
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BioChemical Class |
Transferases of nitrogenous groups
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UniProt ID | |||||
EC Number |
EC 2.6.1.3
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Sequence |
MAPPSVFAEVPQAQPVLVFKLTADFREDPDPRKVNLGVGAYRTDDCHPWVLPVVKKVEQK
IANDNSLNHEYLPILGLAEFRSCASRLALGDDSPALKEKRVGGVQSLGGTGALRIGADFL ARWYNGTNNKNTPVYVSSPTWENHNAVFSAAGFKDIRSYRYWDAEKRGLDLQGFLNDLEN APEFSIVVLHACAHNPTGIDPTPEQWKQIASVMKHRFLFPFFDSAYQGFASGNLERDAWA IRYFVSEGFEFFCAQSFSKNFGLYNERVGNLTVVGKEPESILQVLSQMEKIVRITWSNPP AQGARIVASTLSNPELFEEWTGNVKTMADRILTMRSELRARLEALKTPGTWNHITDQIGM FSFTGLNPKQVEYLVNEKHIYLLPSGRINVSGLTTKNLDYVATSIHEAVTKIQ |
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Pathways | |||||
KEGG Pathway | Alanine, aspartate and glutamate metabolism | ||||
Cysteine and methionine metabolism | |||||
Arginine and proline metabolism | |||||
Tyrosine metabolism | |||||
Phenylalanine metabolism | |||||
Phenylalanine, tyrosine and tryptophan biosynthesis | |||||
Metabolic pathways | |||||
Biosynthesis of antibiotics | |||||
Carbon metabolism | |||||
2-Oxocarboxylic acid metabolism | |||||
Biosynthesis of amino acids | |||||
NetPath Pathway | TSH Signaling Pathway | ||||
IL2 Signaling Pathway | |||||
TGF_beta_Receptor Signaling Pathway | |||||
PANTHER Pathway | Asparagine and aspartate biosynthesis | ||||
PathWhiz Pathway | Arginine and Proline Metabolism | ||||
Cysteine Metabolism | |||||
Phenylalanine and Tyrosine Metabolism | |||||
Tyrosine Metabolism | |||||
Reactome | Gluconeogenesis | ||||
Amino acid synthesis and interconversion (transamination) | |||||
WikiPathways | Glycolysis and Gluconeogenesis | ||||
Metabolism of amino acids and derivatives | |||||
Trans-sulfuration pathway | |||||
Metabolism of carbohydrates | |||||
Alanine and aspartate metabolism | |||||
References |
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