Target Information
Target General Infomation | |||||
---|---|---|---|---|---|
Target ID |
T27944
|
||||
Former ID |
TTDC00043
|
||||
Target Name |
Neuropeptide Y receptor type 4
|
||||
Gene Name |
NPY4R
|
||||
Synonyms |
NPY4-R; PP1; PPYR1; Pancreatic polypeptide receptor 1; NPY4R
|
||||
Target Type |
Clinical Trial
|
||||
Disease | Diabetes [ICD9: 253.5, 588.1; ICD10: E23.2, N25.1] | ||||
Obesity [ICD9: 278; ICD10: E66] | |||||
Schizophrenia [ICD9: 295; ICD10: F20] | |||||
Function |
Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PP, PP (2-36) and [Ile-31, Gln-34] PP > [Pro-34] PYY > PYY and [Leu-31, Pro-34] NPY > NPY > PYY (3-36) and NPY (2-36) > PP (13- 36) > PP (31-36) > NPY free acid.
|
||||
BioChemical Class |
GPCR rhodopsin
|
||||
Target Validation |
T27944
|
||||
UniProt ID | |||||
Sequence |
MNTSHLLALLLPKSPQGENRSKPLGTPYNFSEHCQDSVDVMVFIVTSYSIETVVGVLGNL
CLMCVTVRQKEKANVTNLLIANLAFSDFLMCLLCQPLTAVYTIMDYWIFGETLCKMSAFI QCMSVTVSILSLVLVALERHQLIINPTGWKPSISQAYLGIVLIWVIACVLSLPFLANSIL ENVFHKNHSKALEFLADKVVCTESWPLAHHRTIYTTFLLLFQYCLPLGFILVCYARIYRR LQRQGRVFHKGTYSLRAGHMKQVNVVLVVMVVAFAVLWLPLHVFNSLEDWHHEAIPICHG NLIFLVCHLLAMASTCVNPFIYGFLNTNFKKEIKALVLTCQQSAPLEESEHLPLSTVHTE VSKGSLRLSGRSNPI |
||||
Drugs and Mode of Action | |||||
Inhibitor | Adp[-Trp-Arg-Nva-Arg-Tyr-NH2]2 | Drug Info | [528136] | ||
H-[Trp-Arg-Nva-Arg-Tyr]2-NH2 | Drug Info | [528136] | |||
H-[Trp-Arg-Nva-Arg-Tyr]3-NH2 | Drug Info | [528136] | |||
Pim[-Trp-Arg-Nva-Arg-Tyr-NH2]2 | Drug Info | [528136] | |||
Sub[-Trp-Arg-Nva-Arg-Tyr-NH2]2 | Drug Info | [528136] | |||
Sub[-Tyr-Arg-Leu-Arg-Tyr-NH2]2 | Drug Info | [528136] | |||
[Cys-Trp-Arg-Nva-Arg-Tyr-NH2]2 | Drug Info | [528136] | |||
Agonist | PD-4074 | Drug Info | [543758] | ||
TM30339 | Drug Info | [536490] | |||
[125I]GR231118 | Drug Info | [525704] | |||
Modulator | TM30338 | Drug Info | |||
Pathways | |||||
References | |||||
Ref 525704 | [(125)I]-GR231118: a high affinity radioligand to investigate neuropeptide Y Y(1) and Y(4) receptors. Br J Pharmacol. 2000 Jan;129(1):37-46. | ||||
Ref 528136 | J Med Chem. 2006 Apr 20;49(8):2661-5.Neuropeptide Y (NPY) Y4 receptor selective agonists based on NPY(32-36): development of an anorectic Y4 receptor selective agonist with picomolar affinity. |
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.