Target Information
Target General Infomation | |||||
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Target ID |
T25889
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Former ID |
TTDR00979
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Target Name |
Adenylate cyclase
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Synonyms |
ATP pyrophosphate-lyase; Adenylyl cyclase
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Target Type |
Discontinued
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Disease | Cancer [ICD9: 140-229; ICD10: C00-C96] | ||||
Cardiac failure [ICD10: I50] | |||||
Function |
Catalyzes the formation of the second messenger cAMP from ATP. Its transcript is probably degraded by endoribonuclease LS (rnlA), decreasing cAMP levels and the negative regulator Crp- cAMP, which then induces its own transcription again.
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BioChemical Class |
Phosphorus-oxygen lyases
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Target Validation |
T25889
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EC Number |
EC 4.6.1.1
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Drugs and Mode of Action | |||||
Inhibitor | 2,3,17BETA-TRIHYDROXY-1,3,5(10)-ESTRATRIENE | Drug Info | [551374] | ||
2,5-didesoxy-3-ATP | Drug Info | [529597] | |||
2-hydroxy-17beta-estradiol | Drug Info | [529597] | |||
Adenosine-5'-Rp-Alpha-Thio-Triphosphate | Drug Info | [551391] | |||
Alpha,Beta-Methyleneadenosine-5'-Triphosphate | Drug Info | [551393] | |||
Cyclic Adenosine Monophosphate | Drug Info | [551393] | |||
DEOXYADENOSINE | Drug Info | [526967] | |||
N6-CYCLOPENTYLADENOSINE | Drug Info | [528965] | |||
NSC-270718 | Drug Info | [529597] | |||
NSC-88915 | Drug Info | [529597] | |||
Modulator | Ad5-AC6 | Drug Info | [544174] | ||
References | |||||
Ref 526967 | J Med Chem. 2004 Feb 26;47(5):1207-13.Synthesis of 2',5'-dideoxy-2-fluoroadenosine and 2',5'-dideoxy-2,5'-difluoroadenosine: potent P-site inhibitors of adenylyl cyclase. | ||||
Ref 528965 | J Med Chem. 1991 Dec;34(12):3388-90.Activity of N6-substituted 2-chloroadenosines at A1 and A2 adenosine receptors. | ||||
Ref 529597 | J Med Chem. 2008 Aug 14;51(15):4456-64. Epub 2008 Jul 17.Structure-based development of novel adenylyl cyclase inhibitors. | ||||
Ref 544174 | Unanticipated Signaling Events Associated with Cardiac Adenylyl Cyclase Gene Transfer. J Mol Cell Cardiol. 2011 May; 50(5): 751-758. |
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