Target Information

Target General Infomation
Target ID
T24334
Former ID
TTDR00596
Target Name
Deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial
Gene Name
dut
Synonyms
DUTP pyrophosphatase; DUTPase; Deoxyuridine 5'-triphosphate nucleotidohydrolase; Deoxyuridine triphosphate nucleotidohydrolase; dut
Target Type
Research
Function
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
BioChemical Class
Acid anhydrides hydrolase
Target Validation
T24334
UniProt ID
P06968
EC Number
EC3.6.1.23
Sequence
MKKIDVKILDPRVGKEFPLPTYATSGSAGLDLRACLNDAVELAPGDTTLVPTGLAIHIAD
PSLAAMMLPRSGLGHKHGIVLGNLVGLIDSDYQGQLMISVWNRGQDSFTIQPGERIAQMI
FVPVVQAEFNLVEDFDATDRGEGGFGHSGRQ
Inhibitor 1-(3-tritylaminopropyl)uracil Drug Info [1]
1-[(Z)-4-trityloxy-2-butenyl]uracil Drug Info [1]
1-[2-(trityloxy)ethoxymethyl]uracil Drug Info [1]
1-[4-hydroxy-3-(tritylaminomethyl)butyl]uracil Drug Info [1]
2'-deoxyuridine 5'-alpha,beta-imido-diphosphate Drug Info [2]
2'-Deoxyuridine 5'-Alpha,Beta-Imido-Triphosphate Drug Info [3]
2'-deoxyuridylic acid Drug Info [3]
Acetate Ion Drug Info [3]
Deoxyuridine-5'-Diphosphate Drug Info [2]
Deoxyuridine-5'-Triphosphate Drug Info [3]
Pathways
PANTHER Pathway De novo pyrimidine deoxyribonucleotide biosynthesis
References
REF 1J Med Chem. 2006 Jul 13;49(14):4183-95.Acyclic nucleoside analogues as inhibitors of Plasmodium falciparum dUTPase.
REF 2DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res. 2011 Jan;39(Database issue):D1035-4. Nucleic Acids Res. 2011 January
REF 3How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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