Target Information
| Target General Infomation | |||||
|---|---|---|---|---|---|
| Target ID |
T04741
|
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| Former ID |
TTDR00945
|
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| Target Name |
Phosphoribosylaminoimidazolecarboxamide formyltransferase
|
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| Gene Name |
ATIC
|
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| Synonyms |
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase; AICAR transformylase; AICARFT; ATIC
|
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| Target Type |
Research
|
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| Disease | Cancer [ICD9: 140-229; ICD10: C00-C96] | ||||
| BioChemical Class |
Methyltransferase superfamily
|
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| Target Validation |
T04741
|
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| UniProt ID | |||||
| EC Number |
EC 2.1.2.3
|
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| Sequence |
MAPGQLALFSVSDKTGLVEFARNLTALGLNLVASGGTAKALRDAGLAVRDVSELTGFPEM
LGGRVKTLHPAVHAGILARNIPEDNADMARLDFNLIRVVACNLYPFVKTVASPGVTVEEA VEQIDIGGVTLLRAAAKNHARVTVVCEPEDYVVVSTEMQSSESKDTSLETRRQLALKAFT HTAQYDEAISDYFRKQYSKGVSQMPLRYGMNPHQTPAQLYTLQPKLPITVLNGAPGFINL CDALNAWQLVKELKEALGIPAAASFKHVSPAGAAVGIPLSEDEAKVCMVYDLYKTLTPIS AAYARARGADRMSSFGDFVALSDVCDVPTAKIISREVSDGIIAPGYEEEALTILSKKKNG NYCVLQMDQSYKPDENEVRTLFGLHLSQKRNNGVVDKSLFSNVVTKNKDLPESALRDLIV ATIAVKYTQSNSVCYAKNGQVIGIGAGQQSRIHCTRLAGDKANYWWLRHHPQVLSMKFKT GVKRAEISNAIDQYVTGTIGEDEDLIKWKALFEEVPELLTEAEKKEWVEKLTEVSISSDA FFPFRDNVDRAKRSGVAYIAAPSGSAADKVVIEACDELGIILAHTNLRLFHH |
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| Inhibitor | FAICAR | Drug Info | [1] | ||
| NSC-126445 | Drug Info | [2] | |||
| NSC-26699 | Drug Info | [2] | |||
| NSC-292213 | Drug Info | [2] | |||
| NSC-30171 | Drug Info | [2] | |||
| NSC-324572 | Drug Info | [2] | |||
| NSC-37031 | Drug Info | [2] | |||
| NSC-37173 | Drug Info | [2] | |||
| NSC-45592 | Drug Info | [2] | |||
| NSC-47729 | Drug Info | [2] | |||
| NSC-58046 | Drug Info | [2] | |||
| NSC-88915 | Drug Info | [2] | |||
| References | |||||
| REF 1 | J Biol Chem. 2007 Apr 27;282(17):13033-46. Epub 2007 Feb 26.Structure-based design, synthesis, evaluation, and crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase. | ||||
| REF 2 | J Med Chem. 2004 Dec 30;47(27):6681-90.Virtual screening of human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase against the NCI diversity set by use of AutoDock to identify novel nonfolate inhibitors. | ||||
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