Target General Infomation
Target ID
T02677
Former ID
TTDC00273
Target Name
Baculoviral IAP repeat-containing protein 5
Gene Name
BIRC5
Synonyms
Apoptosis inhibitor 4; Apoptosis inhibitor survivin; Survivin; BIRC5
Target Type
Clinical Trial
Disease Cancer [ICD9: 140-229; ICD10: C00-C96]
Non-small cell lung cancer [ICD10: C33-C34]
Ovarian cancer [ICD9: 183; ICD10: C56]
Solid tumours [ICD9: 140-199, 210-229; ICD10: C00-D48]
Function
May play a role in neoplasia. May counteract a default induction of apoptosis in g2/m phase. Interacts with tubulin. Inhibitor of caspase-3 and caspase-7.
BioChemical Class
Inhibitor of apoptosis
Target Validation
T02677
UniProt ID
Sequence
MGAPTLPPAWQPFLKDHRISTFKNWPFLEGCACTPERMAEAGFIHCPTENEPDLAQCFFC
FKELEGWEPDDDPIEEHKKHSSGCAFLSVKKQFEELTLGEFLKLDRERAKNKIAKETNNK
KKEFEETAKKVRRAIEQLAAMD
Drugs and Mode of Action
Drug(s) ISIS 23722 Drug Info Phase 3 Solid tumours [523959]
CV-9201 Drug Info Phase 1/2 Non-small cell lung cancer [522696]
DPX-Survivac Drug Info Phase 1/2 Ovarian cancer [551020]
EZN-3042 Drug Info Phase 1 Cancer [551623]
Modulator EZN-3042 Drug Info
ISIS 23722 Drug Info
Target Expression Profile (TEP) and Drug Resistance Mutation (DRM)
TEP EXP Info
Pathways
KEGG Pathway Hippo signaling pathway
Hepatitis B
Pathways in cancer
Colorectal cancer
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Angiogenesis
Pathway Interaction Database Aurora B signaling
Validated targets of C-MYC transcriptional activation
FOXM1 transcription factor network
Aurora A signaling
Reactome Separation of Sister Chromatids
Resolution of Sister Chromatid Cohesion
RHO GTPases Activate Formins
Mitotic Prometaphase
WikiPathways IL-4 Signaling Pathway
Apoptosis-related network due to altered Notch3 in ovarian cancer
Mitotic Metaphase and Anaphase
Mitotic Prometaphase
Apoptosis
Interleukin-11 Signaling Pathway
Apoptosis Modulation and Signaling
References
Ref 522696ClinicalTrials.gov (NCT00923312) Trial of an RNActive-Derived Cancer Vaccine in Stage IIIB/IV Non Small Cell Lung Cancer (NSCLC). U.S. National Institutes of Health.
Ref 523959ClinicalTrials.gov (NCT01630733) A Multinational, Randomized, Open-Label Study of Custirsen In Patients With Advanced or Metastatic (Stage IV) Non-Small Cell Lung Cancer. U.S. National Institutes of Health.
Ref 5510202011 Pipeline of Immunovaccine.
Ref 5516232011 Pipeline of Santaris Pharma.
Ref 550441National Cancer Institute Drug Dictionary (drug id 648549).
Ref 5510202011 Pipeline of Immunovaccine.

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