Target General Information
Target ID T96079
Target Name C-X-C chemokine receptor type 4
Synonyms CD184 antigen; CXC-R4; CXCR-4; Chemokine receptor CXCR4; FB22; Fusin; HM89; LCR1; LESTR; Leukocyte-derived seven transmembrane domain receptor; NPYRL; SDF-1 receptor; Stromal cell-derived factor 1 receptor; CXCR4
Target Type Successful
Gene Name CXCR4
Biochemical Class GPCR rhodopsin
UniProt ID CXCR4_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease Acute myelocytic leukemia
Example drug BL-8040 Phase 2 [525271], [1572592]
Tissue Bone marrow
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: -0.40
Z-score: -0.69
P-value: 7.10E-15
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
Disease Sarcoma
Example drug CTCE-9908 Phase 1/2 [530179], [1572592]
Tissue Muscle tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: 2.47
Z-score: 4.78
P-value: 3.40E-206
Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section Fold-change: 2.30
Z-score: 7.61
P-value: 1.56E-04
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
Target gene expression profiles in the tissue of healthy individual
Disease Myeloma
Tissue Bone marrow
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: -0.22
Z-score: -0.36
P-value: 8.30E-02
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Reference
Ref
Ref 530179A CXCR4 antagonist CTCE-9908 inhibits primary tumor growth and metastasis of breast cancer. J Surg Res. 2009 Aug;155(2):231-6.
Ref 525271ClinicalTrials.gov (NCT02502968) BL-8040 Addition to Consolidation Therapy in AML Patients.
Ref 1572592NCBI GEO: archive for functional genomics data sets--update.

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