Target General Information
Target ID T85467
Target Name Prostaglandin E2 receptor EP3
Synonyms PGE receptor, EP3 subtype; PGE2-R; Prostanoid EP3 receptor; PTGER3
Target Type Clinical Trial
Gene Name PTGER3
Biochemical Class GPCR rhodopsin
UniProt ID PE2R3_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease Asthma
Example drug GR-63799X Discontinued in Phase 1 [539236], [545501], [1572592]
Tissue Nasal and bronchial airway
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: 7.51E-03
Z-score: 0.03
P-value: 4.36E-01
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Reference
Ref 545501Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003508)
Ref 539236(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1937).
Ref 1572592NCBI GEO: archive for functional genomics data sets--update.

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