Target expression details
| Target General Information | |||||
|---|---|---|---|---|---|
| Target ID | T73215 | ||||
| Target Name | B lymphocyte surface antigen B1 | ||||
| Synonyms | B-lymphocyte surface antigen B1; Bp35; CD20; Leu-16; MS4A1 | ||||
| Target Type | Successful | ||||
| Gene Name | MS4A1 | ||||
| Biochemical Class | CD20 ca(2+) channel | ||||
| UniProt ID | CD20_HUMAN | ||||
| Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals | |||||
| Disease | Multiple sclerosis | ||||
| Example drug | Ocrelizumab | Approved | [1], [2] | ||
| Tissue | Spinal cord | ||||
| Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section | Fold-change: 0.15 Z-score: 1.27 P-value: 4.83E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
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| Disease | Rheumatoid arthritis | ||||
| Example drug | SBI-087 | Phase 2 | [3], [2] | ||
| Tissue | Synovial tissue | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: 0.25 Z-score: 0.56 P-value: 4.00E-02 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Target Gene Expression Profiles in Other Tissues of Healthy Individuals | |||||
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| Reference | |||||
| REF 1 | Drugs@FDA (Edaravone) | ||||
| REF 2 | NCBI GEO: archive for functional genomics data sets--update. | ||||
| REF 3 | ClinicalTrials.gov (NCT01008852) Study Evaluating The Efficacy And Safety Of SBI-087 In Seropositive Subjects With Active Rheumatoid Arthritis. U.S. National Institutes of Health. | ||||
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