Target expression details
Target General Information | |||||
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Target ID | T62292 | ||||
Target Name | GABA(A) receptor alpha-3 | ||||
Synonyms | GABA(A)Gamma-aminobutyric-acid receptor alpha-3 subunit precursor receptor; GABA-A receptor alpha 3; GABRA3 | ||||
Target Type | Clinical Trial | ||||
Gene Name | GABRA3 | ||||
Biochemical Class | Ligand-gated ion channel | ||||
UniProt ID | GBRA3_HUMAN | ||||
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals | |||||
Disease | Schizophrenia | ||||
Example drug | AZD6280 | Discontinued in Phase 1 | [548677], [1572592] | ||
Tissue | Pre-frontal cortex | ||||
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: -0.26 Z-score: -0.27 P-value: 6.05E-02 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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Disease | Schizophrenia | ||||
Example drug | AZD6280 | Discontinued in Phase 1 | [548677], [1572592] | ||
Tissue | Superior temporal cortex | ||||
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: -0.14 Z-score: -0.36 P-value: 9.54E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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Target Gene Expression Profiles in Other Tissues of Healthy Individuals | |||||
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