Target General Information
Target ID T48873
Target Name Synaptic vesicle amine transporter
Synonyms Monoamine transporter; Solute carrier family 18 member 2; VAT; VMAT; Vesicular Monoamine Transporter ; Vesicular amine transporter; SLC18A2
Target Type Successful
Gene Name SLC18A2
Biochemical Class Major facilitator superfamily
UniProt ID VMAT2_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease Alzheimer's disease
Example drug AV 133 Phase 3 [548627], [1572592]
Tissue Entorhinal cortex
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: -0.04
Z-score: -0.11
P-value: 2.69E-02
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
Reference
Ref 548627Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027191)
Ref 1572592NCBI GEO: archive for functional genomics data sets--update.

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