Target General Information
Target ID	T34296
Target Name	Matrix metalloproteinase-13
Synonyms	Collagenase-3; MMP-13; Matrix metalloproteinase 13; Matrix metalloproteinase-13; MMP13
Target Type	Clinical Trial
Gene Name	MMP13
Biochemical Class	Peptidase
UniProt ID	MMP13_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease	Rheumatoid arthritis
Example drug	Apratastat			Phase 2	[521616], [541616], [1572592]
Tissue	Synovial tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: 0.76 Z-score: 1.30 P-value: 1.25E-03
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Disease	Osteoarthritis
Tissue	Synovial tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual	Fold-change: 0.13 Z-score: 0.10 P-value: 7.39E-01
Target gene expression profiles of the patients in the disease section of the tissue Target gene expression profiles in the tissue of healthy individual Download target gene expression data of the patients in the disease section of the tissue Download target gene expression data in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Download the Expression Profile (Genomics. 86(2):127-41, 2005)
Reference
Ref
Ref 541616	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6482).
Ref 521616	ClinicalTrials.gov (NCT00095342) Study Evaluating TMI-005 in Active Rheumatoid Arthritis. U.S. National Institutes of Health.
Ref 1572592	NCBI GEO: archive for functional genomics data sets--update.

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