Target General Information
Target ID T30687
Target Name mRNA of GRL
Synonyms mRNA of GR; mRNA of GRL; mRNA of NR3C1; mRNA of Nuclear receptor subfamily 3 group C member 1; NR3C1
Target Type Clinical Trial
Gene Name NR3C1
Biochemical Class Zinc-finger
UniProt ID GCR_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease Type 2 diabetes
Example drug A-348441 Phase 1 [528668], [1572592]
Tissue Liver tissue
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: 0.54
Z-score: 1.67
P-value: 3.19E-02
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Reference
Ref 528668Liver-selective glucocorticoid receptor antagonism decreases glucose production and increases glucose disposal, ameliorating insulin resistance. Metabolism. 2007 Mar;56(3):380-7.
Ref 1572592NCBI GEO: archive for functional genomics data sets--update.

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