Target General Information
Target ID T26368
Target Name GABA(A) receptor alpha-5
Synonyms GABA-A alpha-5; GABAA alpha 5; GABRA5
Target Type Clinical Trial
Gene Name GABRA5
Biochemical Class Ligand-gated ion channel
UniProt ID GBRA5_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease Alzheimer's disease
Example drug RG-1662 Phase 2 [525248], [1572592]
Tissue Entorhinal cortex
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: -0.68
Z-score: -0.61
P-value: 3.15E-09
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Reference
Ref 525248ClinicalTrials.gov (NCT02484703) A Study of RG1662 in Down Syndrome Among Children 6 to 11 Years of Age.
Ref 1572592NCBI GEO: archive for functional genomics data sets--update.

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