Target General Information
Target ID T22658
Target Name Interleukin-8
Synonyms Emoctakin; GCP-1; Granulocyte chemotacticprotein 1; IL-8; LYNAP; Lymphocyte-derived neutrophil-activating factor; MDNCF; MONAP; Monocyte derived neutrophil activating peptide; Monocyte-derived neutrophil chemotactic factor; NAF; NAP-1; Neutrophil-activating factor; Neutrophil-activating protein 1; Protein 3-10C; T-cell chemotactic factor; CXCL8
Target Type Clinical Trial
Gene Name CXCL8
Biochemical Class Intercrine-alpha family
UniProt ID IL8_HUMAN
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals
Disease Melanoma
Example drug ABX-IL8 Phase 2 [521511], [1572592]
Tissue Skin
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual Fold-change: 2.09
Z-score: 3.08
P-value: 9.05E-17
Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
Target Gene Expression Profiles in Other Tissues of Healthy Individuals
Reference
Ref 521511ClinicalTrials.gov (NCT00035828) A Blinded Study Comparing the Safety and Efficacy of a Fully Human Anti-IL8 Monoclonal Antibody (ABX-IL8) to Placebo in Patients With Chronic Bronchitis and COPD. U.S. National Institutes of Health.
Ref 1572592NCBI GEO: archive for functional genomics data sets--update.

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