Target expression details
Target General Information | |||||
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Target ID | T11388 | ||||
Target Name | Cathepsin K | ||||
Synonyms | Cathepsin O; Cathepsin O2; Cathepsin X; CTSK | ||||
Target Type | Clinical Trial | ||||
Gene Name | CTSK | ||||
Biochemical Class | Peptidase | ||||
UniProt ID | CATK_HUMAN | ||||
Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals | |||||
Disease | Rheumatoid arthritis | ||||
Example drug | VEL-0230 | Phase 1 | [551545], [1572592] | ||
Tissue | Synovial tissue | ||||
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: 1.59 Z-score: 1.81 P-value: 6.91E-04 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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Disease | Osteoporosis | ||||
Example drug | Balicatib | Discontinued in Phase 2 | [536957], [542791], [1572592] | ||
Tissue | Bone marrow | ||||
Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: -1.14 Z-score: -2.61 P-value: 2.85E-01 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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Target Gene Expression Profiles in Other Tissues of Healthy Individuals | |||||
Reference | |||||
Ref 542791 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7861). | ||||
Ref 536957 | Current and future treatments of bone metastases. Expert Opin Emerg Drugs. 2008 Dec;13(4):609-27. |
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