Target expression details
| Target General Information | |||||
|---|---|---|---|---|---|
| Target ID | T00176 | ||||
| Target Name | Ubiquitin-protein ligase E3 Mdm2 | ||||
| Synonyms | Double minute 2 protein; Hdm2; MDM2 protein; Oncoprotein Mdm2; P53-binding protein Mdm2; MDM2 | ||||
| Target Type | Clinical Trial | ||||
| Gene Name | MDM2 | ||||
| Biochemical Class | Carbon-nitrogen ligase | ||||
| UniProt ID | MDM2_HUMAN | ||||
| Target Gene Expression Profiles in the Disease-Relevant Drug Targeted Tissue of the Patients and Healthy Individuals | |||||
| Disease | Lung cancer | ||||
| Example drug | JNJ-26854165 | Phase 1 | [522321], [1572592] | ||
| Tissue | Lung tissue | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: 0.12 Z-score: 0.44 P-value: 8.31E-13 |
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| Level of differential expression between the patients in the disease section of the tissue and the patients in the normal section of the tissue adjacent to the disease section | Fold-change: 0.19 Z-score: 0.52 P-value: 9.70E-11 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles of the patients in the normal section of the tissue adjacent to the disease section
Target gene expression profiles in the tissue of healthy individual
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| Disease | Prostate cancer | ||||
| Example drug | JNJ-26854165 | Phase 1 | [522321], [1572592] | ||
| Tissue | Prostate | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: 0.05 Z-score: 0.16 P-value: 1.19E-04 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Disease | Acute myelocytic leukemia | ||||
| Tissue | Bone marrow | ||||
| Level of differential expression between the patients in the disease section of the tissue and the tissues of healthy individual | Fold-change: 0.09 Z-score: 0.50 P-value: 1.28E-04 |
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Target gene expression profiles of the patients in the disease section of the tissue
Target gene expression profiles in the tissue of healthy individual
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| Target Gene Expression Profiles in Other Tissues of Healthy Individuals | |||||
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