Drug Information

Drug General Information
Drug ID
D07YGK
Former ID
DIB013959
Drug Name
Vilaprisan
Drug Type
Small molecular drug
Indication Endometriosis [ICD9: 617; ICD10:N80] Phase 2 [525223]
Structure
Download
2D MOL

3D MOL
Formula
C27H29F5O4S
Canonical SMILES
CC12CC(C3=C4CCC(=O)C=C4CCC3C1CCC2(C(C(F)(F)F)(F)F)O)C5=<br />CC=C(C=C5)S(=O)(=O)C
InChI
1S/C27H29F5O4S/c1-24-14-21(15-3-7-18(8-4-15)37(2,35)36)23-19-10-6-17(33)13-16(19)5-9-20(23)22(24)11-12-25(24,34)26(28,29)27(30,31)32/h3-4,7-8,13,20-22,34H,5-6,9-12,14H2,1-2H3/t20-,21+,22-,24-,25-/m0/s1
InChIKey
JUFWQQVHQFDUOD-ANRPBIDPSA-N
PubChem Compound ID
50915138
PubChem Substance ID
113031405, 172650836, 198985445, 228259220
Target and Pathway
Target(s) Progesterone receptor Target Info Antagonist [549227], [551871]
KEGG Pathway Oocyte meiosis
Progesterone-mediated oocyte maturation
Pathway Interaction Database Cellular roles of Anthrax toxin
Reactome Nuclear signaling by ERBB4
Nuclear Receptor transcription pathway
WikiPathways Ovarian Infertility Genes
Signaling by ERBB4
Nuclear Receptors
References
Ref 525223ClinicalTrials.gov (NCT02465814) Assess Safety and Efficacy of Vilaprisan in Patients With Uterine Fibroids.
Ref 549227Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800033939)
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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