Drug General Information
Drug ID	D0Z6IB
Former ID	DIB010021
Drug Name	AVP-786
Indication	Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89]		Phase 1	[526642], [532713]
Company	Avanir pharmaceuticals
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	Sodium-dependent serotonin transporter	Target Info	Modulator	[526642], [532713]
	Sigma(1)-type opioid receptor	Target Info	Modulator	[526642], [532713]
KEGG Pathway	Serotonergic synapse
NetPath Pathway	TCR Signaling Pathway
PANTHER Pathway	5HT1 type receptor mediated signaling pathway
	5HT2 type receptor mediated signaling pathway
	5HT3 type receptor mediated signaling pathway
	5HT4 type receptor mediated signaling pathway
WikiPathways	Monoamine Transport
	SIDS Susceptibility Pathways
	NRF2 pathway
	Synaptic Vesicle Pathway
	Serotonin Transporter ActivityWP2006:miR-targeted genes in squamous cell - TarBase
	miR-targeted genes in lymphocytes - TarBase
References
Ref 526642	Dextromethorphan antagonizes the acute depletion of brain serotonin by p-chloroamphetamine and H75/12 in rats. Brain Res. 1992 Oct 30;594(2):323-6.
Ref 532713	Antitussives and substance abuse. Subst Abuse Rehabil. 2013 Nov 6;4:75-82.
Ref 526642	Dextromethorphan antagonizes the acute depletion of brain serotonin by p-chloroamphetamine and H75/12 in rats. Brain Res. 1992 Oct 30;594(2):323-6.
Ref 532713	Antitussives and substance abuse. Subst Abuse Rehabil. 2013 Nov 6;4:75-82.

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