Drug General Information
Drug ID	D0D8DA
Former ID	DIB013048
Drug Name	KAG-308
Synonyms	EP4 agonists (ulcerative colitis), Kaken
Indication	Ulcerative colitis [ICD9: 556; ICD10:K51]		Investigative	[543780]
Company	Kaken Pharmaceutical Co Ltd
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	Prostaglandin E2 receptor, EP4 subtype	Target Info	Agonist	[543780]
KEGG Pathway	Neuroactive ligand-receptor interaction
	Inflammatory mediator regulation of TRP channels
	Renin secretion
	Pathways in cancer
NetPath Pathway	FSH Signaling Pathway
	IL2 Signaling Pathway
	IL4 Signaling Pathway
	TGF_beta_Receptor Signaling Pathway
Reactome	Prostanoid ligand receptors
	G alpha (s) signalling events
WikiPathways	Prostaglandin Synthesis and Regulation
	GPCRs, Class A Rhodopsin-like
	Vitamin D Receptor Pathway
	Small Ligand GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 543780	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 343).
Ref 543780	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 343).

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