Drug Information
Drug General Information | |||||
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Drug ID |
D0P4DG
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Former ID |
DIB014818
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Drug Name |
S-070
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Synonyms |
S-070; S-158; Targeted synergy program (solid tumor), Sentinel Oncology; Chk1/PARP-1 inhibitors (cancer); Chk1/PARP-1 inhibitors (cancer), Sentinel Oncology
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Indication | Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] | Investigative | [543531] | ||
Company |
Sentinel Oncology Ltd
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Target and Pathway | |||||
Target(s) | Serine/threonine-protein kinase Chk1 | Target Info | Inhibitor | [543531] | |
Poly [ADP-ribose] polymerase-1 | Target Info | Inhibitor | [543709] | ||
PANTHER Pathway | FAS signaling pathway | ||||
Reactome | Activation of ATR in response to replication stress | ||||
Processing of DNA double-strand break ends | |||||
Presynaptic phase of homologous DNA pairing and strand exchange | |||||
G2/M DNA damage checkpoint | |||||
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A | |||||
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complexR-HSA-5696400:Dual Incision in GG-NER | |||||
WikiPathways | DNA Damage Response | ||||
Signaling by SCF-KIT | |||||
ATM Signaling Pathway | |||||
Retinoblastoma (RB) in Cancer | |||||
Integrated Pancreatic Cancer Pathway | |||||
Prostate Cancer | |||||
Integrated Breast Cancer Pathway | |||||
Integrated Cancer pathway | |||||
Cell Cycle | |||||
Cell Cycle Checkpoints | |||||
miRNA Regulation of DNA Damage ResponseWP314:FAS pathway and Stress induction of HSP regulation | |||||
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer | |||||
Nanoparticle triggered regulated necrosis | |||||
Corticotropin-releasing hormone | |||||
References | |||||
Ref 543531 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1987). | ||||
Ref 543709 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2771). |
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