TTD | Drug: D01JPL

Drug General Information
Drug ID	D01JPL
Former ID	DNCL003819
Drug Name	VEGFR3 Monoclonal Antibody
Indication	Cancer [ICD9: 140-229; ICD10:C00-C96]		Phase 1	[549713]
Company	Lilly
Target and Pathway
Target(s)	Vascular endothelial growth factor receptor 3	Target Info	Modulator	[543500]
KEGG Pathway	Ras signaling pathway
	Rap1 signaling pathway
	Cytokine-cytokine receptor interaction
	PI3K-Akt signaling pathway
	Focal adhesion
NetPath Pathway	TNFalpha Signaling Pathway
Pathway Interaction Database	VEGF and VEGFR signaling network
Pathway Interaction Database	VEGFR3 signaling in lymphatic endothelium
Reactome	VEGF binds to VEGFR leading to receptor dimerization
WikiPathways	Signaling by VEGF
References
Ref 549713	J Clin Oncol 29: 2011 (suppl, abstr TPS150).
Ref 543500	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1814).

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Drug Information