Drug Information

Drug General Information
Drug ID
D0T6KV
Former ID
DNCL001961
Drug Name
GSK933776A
Indication Alzheimer disease [ICD9: 331; ICD10:G30] Phase 2 [548646]
Company
GlaxoSmithKline
Target and Pathway
Target(s) Amyloid beta A4 protein Target Info Modulator [544349]
KEGG Pathway Notch signaling pathway
Alzheimer's disease
Reactome Nuclear signaling by ERBB4
Degradation of the extracellular matrix
Regulated proteolysis of p75NTR
NRIF signals cell death from the nucleus
Activated NOTCH1 Transmits Signal to the Nucleus
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
EPH-ephrin mediated repulsion of cells
WikiPathways Notch Signaling Pathway
Signaling by ERBB4
Signaling by NOTCH3
Signaling by NOTCH4
Signaling by NOTCH1
Signaling by NOTCH2
Notch Signaling Pathway
Alzheimers Disease
Signalling by NGF
References
Ref 548646Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027328)
Ref 544349Profile of gantenerumab and its potential in the treatment of Alzheimer's disease. Correction in: Drug Des Devel Ther. 2014; 8: 569.

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