Drug General Information
Drug ID	D0A0SI
Former ID	DNCL003393
Drug Name	BAY 85-8501
Indication	Bronchiectasis [ICD9: 494, 748.61; ICD10:J47, Q33.4]		Phase 2	[549458]
Company	Bayer HealthCare Pharmaceuticals
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	Leukocyte elastase	Target Info	Modulator	[533269]
KEGG Pathway	Transcriptional misregulation in cancer
	Systemic lupus erythematosus
Pathway Interaction Database	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
	C-MYB transcription factor network
Reactome	Collagen degradation
	Degradation of the extracellular matrix
	Activation of Matrix Metalloproteinases
WikiPathways	Hair Follicle Development: Cytodifferentiation (Part 3 of 3)
	Human Complement System
	Degradation of collagen
References
Ref 549458	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800037600)
Ref 533269	Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY??5-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases. ChemMedChem. 2015 Jul;10(7):1163-73.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.