Drug Information

Drug General Information
Drug ID
D0M8PL
Former ID
DIB011332
Drug Name
Angiozyme
Synonyms
RPI-4610; Ribozyme (VEGFr), Ribozyme/Chiron; Ribozyme (VEGFr), Sirna/Chiron
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Discontinued in Phase 2 [546650]
Company
Sirna Therapeutics Inc
CAS Number
CAS 220420-78-0
Target and Pathway
Target(s) Vascular endothelial growth factor receptor 1 Target Info Modulator
KEGG Pathway Ras signaling pathway
Rap1 signaling pathway
Cytokine-cytokine receptor interaction
HIF-1 signaling pathway
Endocytosis
PI3K-Akt signaling pathway
Focal adhesion
Transcriptional misregulation in cancer
Rheumatoid arthritis
Pathway Interaction Database Glypican 1 network
HIF-2-alpha transcription factor network
S1P3 pathway
VEGF and VEGFR signaling network
VEGFR1 specific signals
Signaling events mediated by VEGFR1 and VEGFR2
Reactome Neurophilin interactions with VEGF and VEGFR
VEGF binds to VEGFR leading to receptor dimerization
WikiPathways Focal Adhesion
Signaling by VEGF
Angiogenesis
References
Ref 546650Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009459)

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