Drug General Information
Drug ID	D06KGI
Former ID	DIB001928
Drug Name	TG-0054
Synonyms	CXCR4 binding inhibitor/cell mobilizer (iv, stem cell transplant), TaiGen Biotechnology
Indication	Macular degeneration [ICD9: 362.5; ICD10:H35.3]		Phase 2	[522865]
Company	TaiGen Biotechnology Co Ltd
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	C-X-C chemokine receptor 4	Target Info	Inhibitor	[532779]
KEGG Pathway	Cytokine-cytokine receptor interaction
	Chemokine signaling pathway
	Endocytosis
	Axon guidance
	Leukocyte transendothelial migration
	Intestinal immune network for IgA production
	Pathways in cancer
NetPath Pathway	IL2 Signaling Pathway
	IL4 Signaling Pathway
	Leptin Signaling Pathway
PANTHER Pathway	Axon guidance mediated by Slit/Robo
	Inflammation mediated by chemokine and cytokine signaling pathway
Pathway Interaction Database	S1P3 pathway
	CXCR4-mediated signaling events
	Syndecan-4-mediated signaling events
	HIF-1-alpha transcription factor network
	Ephrin B reverse signaling
Reactome	Binding and entry of HIV virion
	Chemokine receptors bind chemokines
	G alpha (i) signalling events
WikiPathways	GPCRs, Class A Rhodopsin-like
	Hematopoietic Stem Cell Differentiation
	HIV Life Cycle
	Cardiac Progenitor Differentiation
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 522865	ClinicalTrials.gov (NCT01018979) Safety and PK/PD of TG-0054 in Multiple Myeloma, Non-Hodgkin Lymphoma and Hodgkin Disease Patients. U.S. National Institutes of Health.
Ref 532779	CXCR4 Antagonist TG-0054 Mobilizes Mesenchymal Stem Cells, Attenuates Inflammation, and Preserves Cardiac Systolic Function in a Porcine Model of Myocardial Infarction. Cell Transplant. 2015;24(7):1313-28.

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