TTD | Drug: D0E9HQ

Drug General Information
Drug ID	D0E9HQ
Former ID	DCL000618
Drug Name	R7334
Synonyms	R 7334; 2-Nitro-6,7,8,9-tetrahydronaphtho(1,2-b)furan; 2-nitro-6,7,8,9-tetrahydrobenzo[g][1]benzofuran; 6,7,8,9-Tetrahydro-2-nitronaphtho(1,2-b)furan
Drug Type	Antibody
Indication	Macular degeneration [ICD9: 362.5; ICD10:H35.3]		Phase 1	[522356]
Company	Roche
Structure		Download 2D MOL 3D MOL
Formula	C12H11NO3
Canonical SMILES	C1CCC2=C(C1)C=CC3=C2OC(=C3)[N+](=O)[O-]
InChI	1S/C12H11NO3/c14-13(15)11-7-9-6-5-8-3-1-2-4-10(8)12(9)16-11/h5-7H,1-4H2
InChIKey	DZLOYALXDCQGTA-UHFFFAOYSA-N
PubChem Compound ID	55489
PubChem Substance ID	8184163, 43113460, 49996344, 50586351, 103165402, 104307735, 126420567, 135014220
Target and Pathway
Target(s)	Placenta growth factor	Target Info		[551607]
KEGG Pathway	Ras signaling pathway
	Rap1 signaling pathway
	PI3K-Akt signaling pathway
	Focal adhesion
	Pathways in cancer
NetPath Pathway	TSH Signaling Pathway
Pathway Interaction Database	VEGFR1 specific signals
Reactome	VEGF ligand-receptor interactions
Reactome	VEGF binds to VEGFR leading to receptor dimerization
WikiPathways	Focal Adhesion
WikiPathways	Signaling by VEGF
References
Ref 522356	ClinicalTrials.gov (NCT00702494) Phase I Study on Monoclonal Antibody TB-403 Directed Against PlGF in Patients With Solid Tumours. U.S. National Institutes of Health.
Ref 551607	Clinical pipeline report, company report or official report of Roche (2009).

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Drug Information