Drug Information

Drug General Information
Drug ID
D0YX5H
Former ID
DIB005758
Drug Name
Intravenous minocycline
Synonyms
Intravenous minocycline (stroke)
Indication Cerebrovascular ischaemia [ICD9: 434.91; ICD10:I61-I63] Phase 2 [531185]
Company
Medical College of Georgia
Target and Pathway
Target(s) Poly [ADP-ribose] polymerase-1 Target Info Modulator [531185]
KEGG Pathway Base excision repair
NF-kappa B signaling pathway
PANTHER Pathway FAS signaling pathway
Pathway Interaction Database Integrin-linked kinase signaling
Caspase Cascade in Apoptosis
Notch-mediated HES/HEY network
Reactome Dual Incision in GG-NER
WikiPathways FAS pathway and Stress induction of HSP regulation
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
Nanoparticle triggered regulated necrosis
Corticotropin-releasing hormone
References
Ref 531185Minocycline protects cardiac myocytes against simulated ischemia-reperfusion injury by inhibiting poly(ADP-ribose) polymerase-1. J Cardiovasc Pharmacol. 2010 Dec;56(6):659-68.
Ref 531185Minocycline protects cardiac myocytes against simulated ischemia-reperfusion injury by inhibiting poly(ADP-ribose) polymerase-1. J Cardiovasc Pharmacol. 2010 Dec;56(6):659-68.

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