Drug General Information
Drug ID
D0F6CT
Former ID
DCL000119
Drug Name
GI 181771
Drug Type
Small molecular drug
Indication Obesity [ICD9: 278; ICD10:E66] Discontinued in Phase 2 [547133]
Company
GlaxoSmithKline
Structure
Download
2D MOL

3D MOL

Formula
C34H31N5O6
Canonical SMILES
CC(C)N(C1=CC=CC=C1)C(=O)CN2C3=CC=CC=C3N(C(=O)C(C2=O)NC(<br />=O)NC4=CC=CC(=C4)C(=O)O)C5=CC=CC=C5
InChI
1S/C34H31N5O6/c1-22(2)38(25-14-5-3-6-15-25)29(40)21-37-27-18-9-10-19-28(27)39(26-16-7-4-8-17-26)32(42)30(31(37)41)36-34(45)35-24-13-11-12-23(20-24)33(43)44/h3-20,22,30H,21H2,1-2H3,(H,43,44)(H2,35,36,45)/t30-/m0/s1
InChIKey
CABBMMXFOOZVMS-PMERELPUSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Cholecystokinin receptor type A Target Info Agonist [535784]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Insulin secretion
Pancreatic secretion
Reactome Peptide ligand-binding receptors
G alpha (q) signalling events
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 547133Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800013294)
Ref 535784Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2003 Jul-Aug;25(6):483-506.

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