Drug General Information
Drug ID	D0R3EL
Former ID	DCL000372
Drug Name	GSK184072
Drug Type	Small molecular drug
Indication	Colon cancer; Hematologic cancers; Type 2 diabetes [ICD9: 140-229, 250, 250.00, 250.02; ICD10:E08-E13, E11]		Discontinued in Phase 2	[548320]
Company	GSK
Structure		Download 2D MOL 3D MOL
Formula	C12H18N2O3
Canonical SMILES	CC(C)CC1=NC(=CC(C)C)C(=O)N(C1=O)O
InChI	1S/C12H18N2O3/c1-7(2)5-9-11(15)14(17)12(16)10(13-9)6-8(3)4/h5,7-8,17H,6H2,1-4H3/b9-5-
InChIKey	SIXHCCPAJIVTOY-UITAMQMPSA-N
PubChem Compound ID	6443207
PubChem Substance ID	811641, 11969039, 14847386, 43035735, 51449023, 57369372, 103179857, 114567661, 134339021, 134340028, 135165866
Target and Pathway
Target(s)	NAD-dependent deacetylase sirtuin-1	Target Info	Activator	[550963]
KEGG Pathway	FoxO signaling pathway
	AMPK signaling pathway
	Glucagon signaling pathway
	Amphetamine addiction
	MicroRNAs in cancer
PANTHER Pathway	p53 pathway
Pathway Interaction Database	p73 transcription factor network
	Signaling events mediated by HDAC Class III
	E2F transcription factor network
	HIF-2-alpha transcription factor network
	Signaling events mediated by HDAC Class I
	FoxO family signaling
	Regulation of Androgen receptor activity
	Regulation of retinoblastoma protein
Reactome	RORA activates gene expression
	Regulation of HSF1-mediated heat shock response
	Circadian Clock
WikiPathways	Integrated Pancreatic Cancer Pathway
	SREBF and miR33 in cholesterol and lipid homeostasis
	Integrated Breast Cancer Pathway
	SREBP signalling
	Androgen receptor signaling pathway
References
Ref 548320	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800024569)
Ref 550963	Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).

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