Drug Information

Drug General Information
Drug ID
D0IR6K
Former ID
DIB005774
Drug Name
AF-219
Synonyms
AF-742; R-1646; RG-1646; RO-4926219; P2X3 antagonist (pain), Roche; P2X3 antagonist (oral, pain), Afferent Pharmaceuticals
Indication Overactive bladder disorder [ICD9: 188, 596.51; ICD10:C67, N32.81] Phase 2 [525238]
Company
Afferent pharmaceuticals
Structure
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2D MOL

3D MOL
Target and Pathway
Target(s) P2X purinoceptor 3 Target Info Antagonist [533055]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
References
Ref 525238ClinicalTrials.gov (NCT02477709) A Study to Assess the Tolerability of a Single Dose of AF-219 in Subjects With Idiopathic Pulmonary Fibrosis (IPF).
Ref 533055P2X3 receptor antagonist (AF-219) in refractory chronic cough: a randomised, double-blind, placebo-controlled phase 2 study. Lancet. 2015 Mar 28;385(9974):1198-205.

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