Drug Information

Drug General Information
Drug ID
D0G1YO
Former ID
DCL000411
Drug Name
GSK1521498
Synonyms
GSK-1521498; GSK-1521498B
Drug Type
Small molecular drug
Indication Obesity [ICD9: 278; ICD10:E66] Phase 1 [550960]
Company
GlaxoSmithKline
Structure
Download
2D MOL

3D MOL
Formula
C24H20F2N4
Canonical SMILES
C1C(CC2=CC=CC=C21)NCC3=C(C=C(C=C3F)C4=CC(=CC=C4)C5=NC=N<br />N5)F
InChI
1S/C24H20F2N4/c25-22-11-19(15-6-3-7-18(8-15)24-28-14-29-30-24)12-23(26)21(22)13-27-20-9-16-4-1-2-5-17(16)10-20/h1-8,11-12,14,20,27H,9-10,13H2,(H,28,29,30)
InChIKey
WIEDUMBCZQRGSY-UHFFFAOYSA-N
PubChem Compound ID
24737629
PubChem Substance ID
49630889, 99431663, 119754901, 140766780, 162109073, 198942130, 224383253, 227962625, 240728132, 248016442, 249015705
Target and Pathway
Target(s) Mu-type opioid receptor Target Info Agonist [550960], [550963]
KEGG Pathway Neuroactive ligand-receptor interaction
Estrogen signaling pathway
Morphine addiction
NetPath Pathway TCR Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Enkephalin release
Pathway Interaction Database IL4-mediated signaling events
Reactome Peptide ligand-binding receptors
G alpha (i) signalling events
WikiPathways TCR Signaling Pathway
GPCRs, Class A Rhodopsin-like
Peptide GPCRs
Opioid Signalling
GPCR ligand binding
GPCR downstream signaling
References
Ref 550960Clinical pipeline report, company report or official report of GlaxoSmithKline (2011).
Ref 550960Clinical pipeline report, company report or official report of GlaxoSmithKline (2011).
Ref 550963Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).

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