Drug Information

Drug General Information
Drug ID
D0YZ4T
Former ID
DIB005460
Drug Name
SFLT-01
Synonyms
AAV2-sFLT-01; VEGF/PIGF suppression gene therapy (cancer), Genzyme; SFLT-01 gene therapy (wet AMD), AGTC/Genzyme; VEGF suppression gene therapy (wet age-related macular degeneration), Applied Genetic Technologies/ Genzyme
Indication Macular degeneration [ICD9: 362.5; ICD10:H35.3] Phase 1 [522879]
Company
Applied Genetic Technologies Corp
Target and Pathway
Target(s) Vascular endothelial growth factor A Target Info Modulator [531341]
Placenta growth factor Target Info Modulator [531341]
KEGG Pathway Ras signaling pathway
Rap1 signaling pathway
Cytokine-cytokine receptor interaction
HIF-1 signaling pathway
mTOR signaling pathway
PI3K-Akt signaling pathway
VEGF signaling pathway
Focal adhesion
Pathways in cancer
Proteoglycans in cancer
MicroRNAs in cancer
Renal cell carcinoma
Pancreatic cancer
Bladder cancer
Rheumatoid arthritishsa04014:Ras signaling pathway
NetPath Pathway IL2 Signaling Pathway
EGFR1 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
TSH Signaling Pathway
Leptin Signaling Pathway
FSH Signaling PathwayNetPath_23:TSH Signaling Pathway
PANTHER Pathway Angiogenesis
VEGF signaling pathway
Pathway Interaction Database Glypican 1 network
HIF-2-alpha transcription factor network
Beta3 integrin cell surface interactions
S1P3 pathway
Signaling events mediated by TCPTP
S1P1 pathway
Alpha9 beta1 integrin signaling events
Integrins in angiogenesis
VEGFR1 specific signals
HIF-1-alpha transcription factor networkvegfr1_pathway:VEGFR1 specific signals
Reactome Platelet degranulation
Regulation of gene expression by Hypoxia-inducible Factor
VEGF ligand-receptor interactions
VEGF binds to VEGFR leading to receptor dimerizationR-HSA-194313:VEGF ligand-receptor interactions
VEGF binds to VEGFR leading to receptor dimerization
WikiPathways SIDS Susceptibility Pathways
Hypertrophy Model
Endochondral Ossification
Focal Adhesion
Differentiation Pathway
Bladder Cancer
Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
Nifedipine Activity
Aryl Hydrocarbon Receptor
Quercetin and Nf-kB/ AP-1 Induced Cell Apoptosis
Integrated Pancreatic Cancer Pathway
Oncostatin M Signaling Pathway
Allograft Rejection
Integrated Breast Cancer Pathway
Signaling by VEGF
Heart Development
AngiogenesisWP306:Focal Adhesion
References
Ref 522879ClinicalTrials.gov (NCT01024998) Safety and Tolerability Study of AAV2-sFLT01 in Patients With Neovascular Age-Related Macular Degeneration (AMD). U.S. National Institutes of Health.
Ref 531341sFLT01: a novel fusion protein with antiangiogenic activity. Mol Cancer Ther. 2011 Mar;10(3):404-15.

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