Drug Information

Drug General Information
Drug ID
D00UUL
Former ID
DNCL003663
Drug Name
N8-GP
Synonyms
NN7088
Indication Factor VIII deficiency; Haemophilia A [ICD9: 286; ICD10:D66] Phase 3 [524756]
Company
Novo Nordisk
Target and Pathway
Target(s) Coagulation Factor VIIIa Target Info Modulator [532228]
KEGG Pathway Complement and coagulation cascades
PANTHER Pathway Blood coagulation
PathWhiz Pathway Coagulation
Reactome Platelet degranulation
Intrinsic Pathway of Fibrin Clot Formation
Common Pathway of Fibrin Clot Formation
COPII (Coat Protein 2) Mediated Vesicle Transport
Cargo concentration in the ER
WikiPathways Complement and Coagulation Cascades
Blood Clotting Cascade
Formation of Fibrin Clot (Clotting Cascade)
References
Ref 524756ClinicalTrials.gov (NCT02137850) Safety and Efficacy of Turoctocog Alfa Pegol (N8-GP) in Previously Untreated Patients With Haemophilia A. U.S. National Institutes of Health.
Ref 532228Enhancing the pharmacokinetic properties of recombinant factor VIII: first-in-human trial of glycoPEGylated recombinant factor VIII in patients with hemophilia A. J Thromb Haemost. 2013 Apr;11(4):670-8.

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