Drug Information

Drug General Information
Drug ID
D0YO4D
Former ID
DCL000277
Drug Name
LG100268
Synonyms
AmbkkkkK580; LG 100268; LG2; LG-100268; 6-(1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopropyl)nicotinic acid; 6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRONAPHTHALEN-2-YL)CYCLOPROPYL]PYRIDINE-3-CARBOXYLIC ACID; 6-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-cyclopropyl]-nicotinic acid; 6-[1-(3,5,5,8,8-pentamethyl-6,7-dihydronaphthalen-2-yl)cyclopropyl]pyridine-3-carboxylic acid
Drug Type
Small molecular drug
Indication Acquired immune deficiency syndrome [ICD9: 42; ICD10:B20] Discontinued in Phase 1 [539849], [546896]
Company
Ligand Pharmaceuticals
Structure
Download
2D MOL

3D MOL
Formula
C24H29NO2
InChI
InChI=1S/C24H29NO2/c1-15-12-18-19(23(4,5)9-8-22(18,2)3)13-17(15)24(10-11-24)20-7-6-16(14-25-20)21(26)27/h6-7,12-14H,8-11H2,1-5H3,(H,26,27)
InChIKey
SLXTWXQUEZSSTJ-UHFFFAOYSA-N
CAS Number
CAS 153559-76-3
PubChem Compound ID
3922
PubChem Substance ID
5569426, 7888633, 8152465, 14876979, 17396630, 26706533, 29223036, 46505129, 50032010, 53790477, 57322053, 74675773, 93167040, 93580484, 103147498, 103219924, 103941126, 104304910, 117420422, 119523768, 125738002, 126667021, 129255377, 134338934, 135221049, 135650517, 137061743, 137275854, 142528867, 160965165, 162275029, 162796208, 163780440, 164761581, 185963910, 198987930, 202545310, 204370195, 223660191, 223704975, 226641981, 242059770, 252215113, 252271908
Target and Pathway
Target(s) Retinoic acid receptor alpha Target Info Agonist [537277]
KEGG Pathway Pathways in cancer
Transcriptional misregulation in cancer
Acute myeloid leukemia
Pathway Interaction Database Retinoic acid receptors-mediated signaling
Reactome Nuclear Receptor transcription pathway
WikiPathways Vitamin A and Carotenoid Metabolism
Nuclear Receptors in Lipid Metabolism and Toxicity
Integrated Pancreatic Cancer Pathway
Adipogenesis
Nuclear Receptors
References
Ref 539849(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2808).
Ref 546896Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800010920)
Ref 537277Placental steroidogenesis in rats is independent of signaling pathways induced by retinoic acids. Gen Comp Endocrinol. 2009 Sep 15;163(3):285-91. Epub 2009 May 3.

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