Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D0AP4O
|
||||
| Former ID |
DPR000123
|
||||
| Drug Name |
Gem 92
|
||||
| Drug Type |
Antisense drug
|
||||
| Indication | HIV-1 infection [ICD9: 001-139, 042; ICD10:B20-B24] | Discontinued in Phase 1 | [546454] | ||
| Therapeutic Class |
Antisense
|
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| Company |
Idera Pharmaceuticals
|
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| Target and Pathway | |||||
| Target(s) | HIV GAG protein | Target Info | Modulator | ||
| Reactome | Uncoating of the HIV Virion | ||||
| Budding and maturation of HIV virion | |||||
| Integration of provirus | |||||
| Early Phase of HIV Life Cycle | |||||
| Minus-strand DNA synthesis | |||||
| Plus-strand DNA synthesis | |||||
| 2-LTR circle formation | |||||
| Binding and entry of HIV virion | |||||
| Membrane binding and targetting of GAG proteins | |||||
| Assembly Of The HIV Virion | |||||
| Integration of viral DNA into host genomic DNA | |||||
| Autointegration results in viral DNA circles | |||||
| APOBEC3G mediated resistance to HIV-1 infection | |||||
| Vpr-mediated nuclear import of PICs | |||||
| WikiPathways | Host Interactions of HIV factors | ||||
| HIV Life Cycle | |||||
| References | |||||
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