Drug Information

Drug General Information
Drug ID
D06UDV
Former ID
DCL000463
Drug Name
AZD2516
Indication Chronic neuropathic pain [ICD9: 338, 356.0, 356.8, 530,780; ICD10:G64, G90.0, K21, R52, G89] Discontinued in Phase 2 [548860]
Therapeutic Class
Analgesics
Company
AstraZeneca
Target and Pathway
Target(s) Metabotropic glutamate receptor 5 Target Info Antagonist [550288]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Huntington's disease
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Endogenous cannabinoid signaling
Reactome G alpha (q) signalling events
Class C/3 (Metabotropic glutamate/pheromone receptors)
WikiPathways Hypothetical Network for Drug Addiction
GPCRs, Class C Metabotropic glutamate, pheromone
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 548860Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800029648)
Ref 550288Clinical pipeline report, company report or official report of AstraZeneca (2009).

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