Drug General Information
Drug ID	D0U5PT
Former ID	DIB009450
Drug Name	GS-9901
Indication	Hematological malignancies [ICD9: 200-209; ICD10:C81-C86]		Phase 1	[524946]
Structure		Download 2D MOL 3D MOL
Target and Pathway
Target(s)	PI3K delta	Target Info	Inhibitor	[531635], [550822]
BioCyc Pathway	Superpathway of inositol phosphate compounds
	3-phosphoinositide biosynthesis
KEGG Pathway	Inositol phosphate metabolism
	ErbB signaling pathway
	Ras signaling pathway
	Rap1 signaling pathway
	cGMP-PKG signaling pathway
	cAMP signaling pathway
	Chemokine signaling pathway
	HIF-1 signaling pathway
	FoxO signaling pathway
	Phosphatidylinositol signaling system
	Sphingolipid signaling pathway
	mTOR signaling pathway
	PI3K-Akt signaling pathway
	AMPK signaling pathway
	Apoptosis
	Adrenergic signaling in cardiomyocytes
	VEGF signaling pathway
	Osteoclast differentiation
	Focal adhesion
	Signaling pathways regulating pluripotency of stem cells
	Platelet activation
	Toll-like receptor signaling pathway
	Jak-STAT signaling pathway
	Natural killer cell mediated cytotoxicity
	T cell receptor signaling pathway
	B cell receptor signaling pathway
	Fc epsilon RI signaling pathway
	Fc gamma R-mediated phagocytosis
	TNF signaling pathway
	Leukocyte transendothelial migration
	Neurotrophin signaling pathway
	Cholinergic synapse
	Inflammatory mediator regulation of TRP channels
	Regulation of actin cytoskeleton
	Insulin signaling pathway
	Progesterone-mediated oocyte maturation
	Estrogen signaling pathway
	Prolactin signaling pathway
	Thyroid hormone signaling pathway
	Oxytocin signaling pathway
	Regulation of lipolysis in adipocytes
	Type II diabetes mellitus
	Non-alcoholic fatty liver disease (NAFLD)
	Aldosterone-regulated sodium reabsorption
	Carbohydrate digestion and absorption
	Bacterial invasion of epithelial cells
	Chagas disease (American trypanosomiasis)
	Toxoplasmosis
	Amoebiasis
	Hepatitis C
	Hepatitis B
	Measles
	Influenza A
	HTLV-I infection
	Epstein-Barr virus infection
	Pathways in cancer
	Viral carcinogenesis
	Proteoglycans in cancer
	Colorectal cancer
	Renal cell carcinoma
	Pancreatic cancer
	Endometrial cancer
	Glioma
	Prostate cancer
Melanoma
Chronic myeloid leukemia
Acute myeloid leukemia
Small cell lung cancer
Non-small cell lung cancer
Central carbon metabolism in cancer
Choline metabolism in cancer
NetPath Pathway	FSH Signaling Pathway
PANTHER Pathway	Angiogenesis
	Apoptosis signaling pathway
	Axon guidance mediated by netrin
	B cell activation
	EGF receptor signaling pathway
	Endothelin signaling pathway
	FGF signaling pathway
	Hypoxia response via HIF activation
	Inflammation mediated by chemokine and cytokine signaling pathway
	Insulin/IGF pathway-protein kinase B signaling cascade
	Integrin signalling pathway
	PDGF signaling pathway
	T cell activation
	VEGF signaling pathway
	p53 pathway
	Ras Pathway
	p53 pathway feedback loops 2
Pathway Interaction Database	ErbB4 signaling events
	TRAIL signaling pathway
	Signaling events mediated by TCPTP
	FAS (CD95) signaling pathway
	CXCR4-mediated signaling events
	EGF receptor (ErbB1) signaling pathway
	Class I PI3K signaling events
	ErbB1 downstream signaling
	ErbB2/ErbB3 signaling events
	PDGFR-beta signaling pathway
	Nephrin/Neph1 signaling in the kidney podocyte
	Internalization of ErbB1
	CXCR3-mediated signaling events
PathWhiz Pathway	Phosphatidylinositol Phosphate Metabolism
Reactome	GPVI-mediated activation cascade
	PIP3 activates AKT signaling
	Constitutive Signaling by Aberrant PI3K in Cancer
	G beta:gamma signalling through PI3Kgamma
	Interleukin-3, 5 and GM-CSF signaling
	Interleukin receptor SHC signaling
	Regulation of signaling by CBL
	Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
WikiPathways	Toll-like receptor signaling pathway
	DNA Damage Response (only ATM dependent)
	Interferon type I signaling pathways
	G13 Signaling Pathway
	Regulation of Actin Cytoskeleton
	Insulin Signaling
	IL-4 Signaling Pathway
	Focal Adhesion
	IL-3 Signaling Pathway
	PI Metabolism
	Signaling by the B Cell Receptor (BCR)
	Interleukin-2 signaling
	PIP3 activates AKT signaling
	Nanoparticle-mediated activation of receptor signaling
	Signaling Pathways in Glioblastoma
	Interleukin-3, 5 and GM-CSF signaling
	MicroRNAs in cardiomyocyte hypertrophy
	Regulation of toll-like receptor signaling pathway
	AMPK Signaling
References
Ref 524946	ClinicalTrials.gov (NCT02258555) Safety, Pharmacodynamics, Pharmacokinetics, and Efficacy of GS-9901 in Adults With Relapsed or Refractory Follicular Lymphoma, Marginal Zone Lymphoma, Chronic Lymphocytic Leukemia, or Small Lymphocytic Lymphoma. U.S. National Institutes of Health.
Ref 531635	Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Res. 2012 Jan;40(Database issue):D1128-36.
Ref 550822	Clinical pipeline report, company report or official report of Gilead.

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