Drug General Information
Drug ID	D0S9MD
Former ID	DIB016152
Drug Name	DFP-11207
Indication	Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48]		Phase 1	[524804]
Company	Delta-fly pharma
Structure		Download 2D MOL
Target and Pathway
Target(s)	Thymidylate synthase	Target Info	Inhibitor	[550515]
BioCyc Pathway	Pyrimidine deoxyribonucleotides biosynthesis from CTP
	Pyrimidine deoxyribonucleotides de novo biosynthesis
	Superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis
	Superpathway of pyrimidine deoxyribonucleoside salvage
	DTMP de novo biosynthesis (mitochondrial)
	Pyrimidine deoxyribonucleosides salvage
KEGG Pathway	Pyrimidine metabolism
	One carbon pool by folate
	Metabolic pathways
PANTHER Pathway	De novo pyrimidine deoxyribonucleotide biosynthesis
	Formyltetrahydroformate biosynthesis
Pathway Interaction Database	E2F transcription factor network
PathWhiz Pathway	Pyrimidine Metabolism
Reactome	E2F mediated regulation of DNA replication
	Pyrimidine biosynthesis
	G1/S-Specific Transcription
WikiPathways	Trans-sulfuration and one carbon metabolism
	Retinoblastoma (RB) in Cancer
	One Carbon Metabolism
	Integrated Pancreatic Cancer Pathway
	miR-targeted genes in muscle cell - TarBase
	miR-targeted genes in lymphocytes - TarBase
	miR-targeted genes in leukocytes - TarBase
	miR-targeted genes in epithelium - TarBase
	Metabolism of nucleotides
	Fluoropyrimidine Activity
References
Ref 524804	ClinicalTrials.gov (NCT02171221) Phase I Study of Oral DFP-11207 in Solid Tumors. U.S. National Institutes of Health.
Ref 550515	National Cancer Institute Drug Dictionary (drug id 762603).

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