Drug Information
Drug General Information | |||||
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Drug ID |
D02JNX
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Former ID |
DIB003092
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Drug Name |
OxycoDex
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Synonyms |
Oxycodone/dextromethorphan
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Indication | Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89] | Discontinued in Phase 2 | [547593] | ||
Company |
Endo Pharmaceuticals
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Target and Pathway | |||||
Target(s) | Opioid receptor | Target Info | Modulator | [531999] | |
Sodium-dependent serotonin transporter | Target Info | Inhibitor | [526642], [532713] | ||
Sigma(1)-type opioid receptor | Target Info | Modulator | [526642], [532713] | ||
KEGG Pathway | Serotonergic synapse | ||||
NetPath Pathway | TCR Signaling Pathway | ||||
References | |||||
Ref 526642 | Dextromethorphan antagonizes the acute depletion of brain serotonin by p-chloroamphetamine and H75/12 in rats. Brain Res. 1992 Oct 30;594(2):323-6. | ||||
Ref 531999 | Differential activation of the ?-opioid receptor by oxycodone and morphine in pain-related brain regions in a bone cancer pain model. Br J Pharmacol. 2013 Jan;168(2):375-88. | ||||
Ref 532713 | Antitussives and substance abuse. Subst Abuse Rehabil. 2013 Nov 6;4:75-82. |
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