Drug Information

Drug General Information
Drug ID
D04ZWH
Former ID
DNC001486
Drug Name
UK-279,276
Indication Stroke [ICD9: 434.91, 437.6, 453, 671.5, 671.9; ICD10:I61-I63, I80-I82] Discontinued in Phase 2 [545570]
Company
Corvas
CAS Number
CAS 166518-60-1
Target and Pathway
Target(s) Integrin beta-2 Target Info Antagonist [536373]
KEGG Pathway Rap1 signaling pathway
Phagosome
Hippo signaling pathway
Cell adhesion molecules (CAMs)
Natural killer cell mediated cytotoxicity
Leukocyte transendothelial migration
Regulation of actin cytoskeleton
Pertussis
Legionellosis
Leishmaniasis
Malaria
Amoebiasis
Staphylococcus aureus infection
Tuberculosis
HTLV-I infection
Rheumatoid arthritis
Viral myocarditis
NetPath Pathway IL5 Signaling Pathway
TCR Signaling Pathway
IL2 Signaling Pathway
PANTHER Pathway Integrin signalling pathway
Pathway Interaction Database Integrin family cell surface interactions
amb2 Integrin signaling
Beta2 integrin cell surface interactions
Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
CXCR3-mediated signaling events
HIF-1-alpha transcription factor network
Reactome Toll Like Receptor 4 (TLR4) Cascade
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Cell surface interactions at the vascular wall
Integrin cell surface interactions
WikiPathways Focal Adhesion
Human Complement System
Toll-Like Receptors Cascades
Integrin-mediated Cell Adhesion
Integrin cell surface interactions
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Cell surface interactions at the vascular wall
References
Ref 545570Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003726)
Ref 536373Advances in ischemic stroke treatment: neuroprotective and combination therapies. Expert Opin Emerg Drugs. 2007 Mar;12(1):97-112.

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