Drug Information
Drug General Information | |||||
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Drug ID |
D00UQW
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Former ID |
DNCL003710
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Drug Name |
RG7741
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Synonyms |
GDC-0575
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Indication | Lymphoma [ICD9: 202.8, 208.9; ICD10:C81-C86] | Phase 1 | [549233] | ||
Company |
Roche
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Target and Pathway | |||||
Target(s) | Serine/threonine-protein kinase Chk1 | Target Info | Modulator | [544397], [550488] | |
Pathway Interaction Database | Fanconi anemia pathway | ||||
p73 transcription factor network | |||||
ATR signaling pathway | |||||
Circadian rhythm pathway | |||||
p53 pathway | |||||
Reactome | Activation of ATR in response to replication stress | ||||
Processing of DNA double-strand break ends | |||||
Presynaptic phase of homologous DNA pairing and strand exchange | |||||
G2/M DNA damage checkpoint | |||||
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A | |||||
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex | |||||
References |
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